PReS-FINAL-2347: Does switching anti-TNFΑ biologic agents an effective option in childhood chronic uveitis: the evidence from a systematic review and meta-analysis approach
نویسندگان
چکیده
Methods A systematic search between January 2000 and May 2013 was conducted using EMBASE, Ovid MEDLINE, Evidence Based Medicine Reviews-ACP Journal Club, Cochrane libraries, and EBM Reviews. Studies investigating the efficacy of anti-TNFa therapy, as the second biologic treatment for ACU, in children (≤16 yrs) refractory to a first course of a single anti-TNFa treatment, topical and/or systemic steroid therapy and at least one DMARD, were eligible for inclusion. The primary outcome measure was the improvement of intraocular inflammation, as defined by the SUN working group criteria, at 6 (± 2) month follow-up on treatment.
منابع مشابه
Superior efficacy of Adalimumab in treating childhood refractory chronic uveitis when used as first biologic modifier drug: Adalimumab as starting anti-TNF-α therapy in childhood chronic uveitis
BACKGROUND Nonetheless biologic modifier therapies are available treatment strategies for sight-threatening uveitis in children, the lack of evidence from head-to-head randomized controlled studies limits our understanding of timing of therapy when to commence therapy, which agent to choose and how long to continue treatment, and, in case of failure, if switching to another anti-TNF-α strategy ...
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2013